Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

18 Item(s)

per page
Axon ID Name Description From price
1506 WZ 4002 EGFR kinase inhibitor (T790M specific) €70.00
3802 TAS6417 EGFR inhibitor Inquire
2053 TAK 165 ErbB2/HER2 kinase inhibitor €60.00
1665 Pelitinib EGFR tyrosine kinase inhibitor €90.00
1632 OSI 420 EGFR tyrosine kinase inhibitor €90.00
4144 Olmutinib Orally bioavailable and irreversible Tyrosine Kinase Inhibitor Inquire
2955 NSC 228155 EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction €75.00
1393 Gefitinib EGFR tyrosine kinase inhibitor €70.00
1128 Erlotinib hydrochloride EGFR tyrosine kinase inhibitor €70.00
3192 EMI48 Inhibitor of EGFR triple mutants €120.00
1760 EGFR Inhibitor [879127-07-8] Highly selective EGFR tyrosine kinase inhibitor €120.00
2680 EAI045 Allosteric EGFR inhibitor (L858R/T790M-specific) €105.00
1433 CI 1033 EGFR tyrosine kinase inhibitor €60.00
2342 AZD9291 Potent oral, irreversible, third-generation EGFR TKI with selectivity for mutant EGFRs €95.00
2563 AZD3759 Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor €85.00
4074 AZ5104 EGFR inhibitor Inquire
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €90.00
3040 Abivertinib Potent oral, irreversible, third-generation EGFR TKI with selectivity for mutant EGFRs €95.00

18 Item(s)

per page
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