Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
3340 ETC-206 Potent, selective and orally available MNK1/2 inhibitor €130.00
2701 EED226 Potent, selective and orally bioavailable PRC2 inhibitor €90.00
3398 E7449 mesylate Potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and TNKS1/2 €110.00
3412 DTHIB Direct and selective HSF1 inhibitor €90.00
1268 DR 2313 PARP inhibitor €90.00
1935 DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) €105.00
1815 Delavirdine NNRT inhibitor (HIV-1) €90.00
1590 Decitabine DNA methyltransferase inhibitor €85.00
1534 Dapivirine NNRT inhibitor €80.00
3238 Cytarabine Inhibitor of DNA synthesis; Antimetabolite €50.00
2173 CX 5461 Inhibitor of RNA Polymerase I (RNAP1) €120.00
2455 CU-T12-9 Selective TLR1/TLR2 agonist that facilitates the TLR1/2 complex formation €120.00
2391 CS1 TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects €135.00
1495 CP 466722 ATM inhibitor €70.00
2841 COTI-2 Reactivator of mutant p53 €125.00
1636 CHIR 124 CHK1 inhibitor €60.00
1611 CGP 57380 Mnk1 inhibitor €95.00
2699 CCT251236 HSF1 stress pathway inhibitor €145.00
3394 CADD522 Potent inhibitor of RUNX2-DNA binding €90.00
2462 BMH 21 Inhibitor of RNA Polymerase I (RNAP1) €95.00
2301 BIBR 1532 Potent and selective telomerase inhibitor inducing senescence in human cancer cells. €70.00
1399 AZD 7762 hydrochloride CHK inhibitor €60.00
2241 AZD 2461 PARP inhibitor with poor P-glycoprotein substrate qualities €95.00
1464 AZD 2281 PARP inhibitor €50.00
2839 AS 1842856 Inhibitor of the Forkhead box protein O1 (FOXO1) €95.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €130.00
3220 ARN24139 Orally active topoisomerase II poison €130.00
2136 AR03 Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €105.00
2137 APE1 Inhibitor III Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €105.00
3008 AOH1160 First-in-class, potent and orally available PCNA inhibitor €120.00

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