Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2604 KU 0060648 DNA-PK inhibitor €125.00
2001 KU 0058948 hydrochloride Potent and specific PARP1 inhibitor €135.00
2538 KRIBB11 HSF1 inhibitor that blocks the induction of HSP27 and HSP70 €125.00
2336 KPT-330 Potent, selective and orally available XPO-1 inhibitor €90.00
2597 KPT 335 XPO1 inhibitor; selective inhibitor of nuclear export (SINE) €95.00
3730 KB-0742 dihydrochloride Orally bioavailable, potent and selective CDK9 inhibitor  Recently added Inquire
1922 JW 55 Inhibitor of tankyrase (TNKS 1 and 2) €95.00
3002 JH-RE-06 Specific and in vivo active REV1-REV7 interaction inhibitor €145.00
2510 IWR-1-endo Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 €85.00
3370 Irinotecan hydrochloride Prodrug of SN-38; Topoisomerase I (Topo 1) inhibitor €80.00
1656 Irestatin 9389 IRE1 inhibitor; UPR inhibitor €125.00
1566 Iniparib PARP inhibitor €60.00
3417 IMT1B First-in-class, potent and highly specific allosteric POLRMT inhibitor €130.00
3107 Imiquimod TLR7/TLR8 agonist €60.00
2101 HSF1B Human HSF1 activator €125.00
1890 HSF1A Human HSF1 activator €125.00
3667 Homoharringtonine Protein synthesis inhibitor; Binds the 60S ribosomal subunit  Recently added €100.00
2614 HIF-2a Translation Inhibitor 76 HIF-2a translation inhibitor that works independent of mTOR €70.00
2034 HIF-2 inhibitor 2 Allosteric inhibitor of HIF-2 €95.00
2390 HAMNO Novel protein interaction inhibitor of replication protein A (RPA) €85.00
2198 Genz 644282 Topo I inhibitor lacking MDR1 and BCRP affinity €95.00
3233 Gemcitabine hydrochloride Specific inhibitor of DNA synthesis; Antimetabolite €50.00
2885 GeA-69 Selective allosteric and cell-active PARP14 MD2 inhibitor €95.00
2157 FQI 1 Inhibitor of α-globin transcription factor CP2 (LSF) €95.00
2959 FM19G11 Potent HIFα inhibitor €95.00
3457 Fludarabine Inhibitor of DNA synthesis; STAT-1 activation inhibitor €50.00
3027 FEN1 inhibitor 1 Potent flap endonuclease-1 (FEN1) inhibitor €135.00
2384 FDI 6 Inhibitor of the Forkhead box protein M1 (FOXM1) €99.00
2318 FC 99 hydrochloride Inhibitor of TLR3 expression and inflammatory responses. €95.00
2975 Fatostatin hydrobromide Specific inhibitor of SREBP cleavage-activating protein (SCAP) €90.00

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