Cell Signaling & Oncology
The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].
Cell Signaling and Oncology products Library
For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.
Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.
 Axon 5051 - Cell signaling and Oncology Library.xls |
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[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3790 | ZINC69391 | Specific Rac1 inhibitor | €110.00 | |
| 2138 | ZCL 278 | Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction | €105.00 | |
| 2816 | WX-132-18B | Tubulin-polymerization inhibitor targeting the colchicine site | €115.00 | |
| 1804 | Wiskostatin | Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) | €105.00 | |
| 2073 | UK 383367 | Inhibitor of bone morphogenetic protein 1 (BMP-1, aka PCP) | €110.00 | |
| 2111 | UK 356618 | Potent MMP-3 (aka Stromelysin-1) inhibitor | €130.00 | |
| 3400 | Tubulin inhibitor 6 | Tubulin polymerization inhibitor; iHAP | €90.00 | |
| 2398 | Suprafenacine | Destabilizer of microtubules that causes cell cycle arrest in the G2/M phase | €110.00 | |
| 2815 | SP-6-27 | Microtubule inhibitor | €125.00 | |
| 2370 | SB-3CT | Potent and selective inhibitor of Gelatinases MMP-2 and MMP-9 | €125.00 | |
| 3804 | Sabizabulin | Orally bioavailable and highly potent tubulin polymerization inhibitor | €220.00 | |
| 3083 | PVHD121 | Microtubule inhibitor | €120.00 | |
| 2328 | PTIQ | Neuroprotectant with attenuating effects on MMP-3 expression | €125.00 | |
| 3368 | Podophyllotoxin | Tubulin polymerization inhibitor | €40.00 | |
| 1181 | PF 00356231 | MMP-12 inhibitor | €140.00 | |
| 1271 | PD166793 | MMP inhibitor | €110.00 | |
| 2393 | NSC 756093 | Potent in vitro inhibitor of GBP1:PIM1 interaction | €125.00 | |
| 2162 | NSC 405020 | MT1-MMP inhibitor specifically targeting PEX-domain. | €85.00 | |
| 1578 | NSC 23766 | Rac1 inhibitor | €110.00 | |
| 1310 | Myoseverin | Tubulin polymerization inhibitor | €125.00 | |
| 2658 | MPT0B098 | Microtubule inhibitor that suppresses JAK2/STAT3 signaling | €105.00 | |
| 2777 | MBQ-167 | Dual Rac and Cdc42 inhibitor | €105.00 | |
| 2406 | IMM 01 | Small-molecule agonist of mammalian Diaphanous (mDia)-related formins | €95.00 | |
| 4029 | Hydroxy-Dynasore | Cell-permeable dynamin inhibitor; MUS81-EME1/2 inhibitor | Recently added | €90.00 |
| 1650 | HTI 286 | Tubulin polymerization inhibitor | €140.00 | |
| 2351 | EHop 016 | Rac GTPase inhibitor specific for Rac1 and Rac3 | €85.00 | |
| 3879 | Dynasore | Noncompetitive cell-permeable dynamin inhibitor | €80.00 | |
| 2104 | CP 471474 | MMP inhibitor | €95.00 | |
| 1233 | Combretastatin-A4 | Tubulin polymerization inhibitor | €85.00 | |
| 3371 | Colchicine | Tubulin polymerization inhibitor | €50.00 | |