Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   


[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

14 Item(s)

per page
Axon ID Name Description From price
3789 YH-306 FAK inhibitor €90.00
3866 TAE226 Potent and ATP-competitive dual FAK and IGF-1R inhibitor €110.00
3676 PKN3 inhibitor compound 16 Potent, cell-active protein kinase novel 3 (PKN3) inhibitor €130.00
3961 PF-03758309 Potent and ATP-competitive inhibitor of p21-activated kinase (PAK4) Inquire
3986 N-Desmethyltamoxifen hydrochloride Metabolite of Tamoxifen (Axon 3252); PKC inhibitor €180.00
3843 LYN-1604 dihydrochloride Potent ULK1 agonist €130.00
3851 LXS-196 Potent and selective protein kinase C inhibitor Inquire
3780 LMTK3 inhibitor C28 Potent LMTK3 inhibitor €120.00
3853 BMS-599626 Potent and selective EGFR and ErbB2 inhibitor Inquire
3939 Bisindolylmaleimide IV Potent PKC inhibitor €120.00
3936 Bisindolylmaleimide I Potent and selective PKC inhibitor €120.00
3771 AZD2858 Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00
2757 Asciminib Potent and selective allosteric BCR-ABL1 inhibitor €120.00
2717 Apigenin Selective inhibitor of Casein kinase 2 (CK2) €70.00

14 Item(s)

per page
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