- Home
- Products
- Research Areas
- Cell Signaling & Oncology
Cell Signaling & Oncology
The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].
Cell Signaling and Oncology products Library
For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.
Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.
Axon 5051 - Cell signaling and Oncology Library.xls | |
[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1639 | YM155 | Survivin suppressant | €95.00 | |
1985 | Xevinapant | Antagonist of Inhibitor of apoptosis proteins (IAPs) | €145.00 | |
2165 | S 12 | Survivin inhibitor | €105.00 | |
3344 | LQZ-7I | Orally active survivin-targeting inhibitor | €90.00 | |
3902 | LCL-161 | IAP inhibitor | Inquire | |
4023 | Embelin | Potent and cell-permeable inhibitor of XIAP | €60.00 | |
4150 | Birinapant | Bivalent Smac mimetic and potent antagonist for XIAP and cIAP1 inhibitor | Inquire | |
4139 | AZD5582 dihydrochloride | Apoptosis proteins (IAPs) inhibitor | Inquire |
- Filter by Endogenous Substrate
- (S)-Palmitoylated proteins (1)
- 2-Arachidonoyl glycerol (2-AG) (3)
- 3-Phosphoglycerate (2)
- Acetylcholine (2)
- Ack1-AR-ATM signaling (3)
- Adenosine (5)
- Adiponectin (1)
- AKT/GSK-3β/Snail signaling (1)
- Alcohol (3)
- Aldose (1)
- AMP (1)
- Amyloids (14)
- Androgen Receptor (AR) (1)
- Androgenic Hormones (6)
- Androgenic hormones (4)
- Androgenic Hormones;Estrogen (1)
- Angiotensin (1)
- Antioxidant (1)
- AP2 (1)
- APP (1)
- ATP (15)
- B-Cell Transformation (8)
- B-Cell transformation (3)
- BCAA (1)
- C-Nap1;PP1;Nek2 (1)
- Calcitriol (3)
- Calcium (14)
- cAMP (17)
- Cannabinoids (1)
- Carbondioxide (2)
- Caspase
- Cell Cycle Regulation (2)
- Cellular Metabolic Homeostasis (2)
- Ceramide (1)
- cGMP (5)
- Chemokine (13)
- Chenodeoxycholic acid (3)
- Chloride (7)
- Cholesterol (1)
- Chromatin (2)
- Citric acid (2)
- Coagulation (2)
- Collagen (1)
- Cyclic 2'3'- cGAMP (1)
- Cyclin dependent (CDK) (7)
- Cyclin Dependent (CDK) (20)
- Cyclopamine (7)
- Cysteinyl leukotrienes (2)
- Cytoskeleton (31)
- Dehydroepiandrosterone;Androstenedione (1)
- Deoxyuridine monophosphate (dUMP) (5)
- Diacylglycerol (3)
- DNA (8)
- DNA-CDN (8)
- DNA-damage response (5)
- DNA-RNA (159)
- dNTP (oxidized) (4)
- Dopamine (1)
- ECM-adhesion (11)
- EGF (18)
- EGF-VEGF (2)
- Eicosanoid epoxides (2)
- Endothelin (1)
- Endothelin;Non Selective (1)
- Ephrins (1)
- Estrogen (19)
- Estrogen, Unfolded Protein Response (Non Selective) (2)
- Farnesyl substrates (CaaX motif) (1)
- Fatty acid (Amides) (1)
- Fatty acid (Arachidonic acid) (2)
- Fatty acid (Linoleic acid) (1)
- Fatty acids (3)
- FFA (3)
- FGF (10)
- FGF-VEGF (2)
- FLT3LG (4)
- Fructose 6-phosphate (3)
- G-Proteins (1)
- Gas6 (3)
- GDNF (3)
- GLP1 (2)
- Glucocorticoid (4)
- Gluconeogenesis (1)
- Glucose (5)
- Glucose Homeostasis (4)
- Glutamate oxaloacetate (1)
- Glutamine (1)
- Glutathion (GSH) (1)
- Glutathione disulfide,Thioredoxin (1)
- Glycans (1)
- Glyceraldehyde 3-phosphate (1)
- Glycogen (1)
- Glycosides (1)
- GnRH (1)
- GPCR-independent noncanonical G-protein signaling (1)
- GTP (16)
- Hedgehog (4)
- HGF (14)
- HGF-VEGF (2)
- Hippo signaling pathway (3)
- Histone (130)
- HMG-CoA (3)
- Hypoxia-signaling cascade (6)
- IGF1 (5)
- IGF2 (1)
- Immunology (3)
- Inosine monophosphate (IMP) (1)
- Inositol-1,4,5-trisphosphate (InsP3) (1)
- Interleukin (10)
- Intracellular Transcription Factors (3)
- Isocitrate (6)
- IκB (8)
- JAK-STAT Pathway (21)
- Kinins (3)
- L-Arginine (3)
- L-Kynurenine (7)
- Lactate (2)
- Lands cycle (1)
- LRP5 (1)
- Mannosidose (α form) (1)
- MAPK (50)
- MEK (17)
- Metabolism (6)
- Methionine (1)
- MHC class II,FGL1 (1)
- Microtubules (7)
- Mono-amines (1)
- Monocarboxylates (2)
- NADH (2)
- NADP+ (1)
- Natural product (7)
- NEDD8 (1)
- Neuropeptide S (1)
- Neurotrophin (7)
- NF-κB pathway (1)
- NF-κB Pathway (6)
- Nicotinamide D-ribonucleotide (4)
- Non Selective (75)
- Non Selective (ADF-cofilin) (4)
- Non Selective (Anions) (1)
- Non Selective (Arginine Sites Proteins) (10)
- Non Selective (Arginine sites proteins) (5)
- Non Selective (Cations) (7)
- Non Selective (CHK2,p53) (2)
- Non Selective (CHK2; p53) (7)
- Non Selective (CHK2;p53) (1)
- Non Selective (Cysteine Peptide Bonds) (3)
- Non Selective (Glucocorticoid) (1)
- Non Selective (Histone; Survivin; Topo) (3)
- Non Selective (Histone; Survivin; Topo; TPX2) (5)
- Non Selective (Histone; Survivin; Topo; TPX2); JAK-STAT Pathway; Non Selective (Phosphorylation Substrates) (1)
- Non Selective (Ions; Na+H+) (1)
- Non Selective (LIM; p53; TPX2) (5)
- Non Selective (LIM;p53;TPX2) (3)
- Non Selective (Lysine Sites Proteins) (1)
- Non Selective (Methionine Peptide Bonds) (1)
- Non Selective (Mitotic spindle checkpoint) (1)
- Non Selective (Mitotic Spindle Checkpoint) (4)
- Non Selective (Phosphorylation substrates) (15)
- Non Selective (Phosphorylation Substrates) (92)
- Non Selective (Phosphorylation Substrates); MAPK (1)
- Non Selective (Phosphorylation Substrates); MAPK; FGF-VEGF (1)
- Non Selective (Proline Peptide Bonds) (3)
- Non Selective (Ribosomal proteins) (9)
- Non Selective (Serine Peptide Bonds) (2)
- Non Selective (Serine peptide bonds) (4)
- Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) (7)
- Non Selective (Serine-Threonine;Tyrosine Specific Phosphodiesters) (1)
- Non Selective (Thiols) (1)
- Non Selective (Tripeptides) (1)
- Non Selective (Tyrosine specific phosphomonoesters) (5)
- Non Selective (Tyrosine Specific Phosphomonoesters) (11)
- Non Selective (Ubiquitin peptides) (36)
- Odor molecule (1)
- Oligosaccharide (1)
- Opioids (1)
- Orexin (3)
- Ornithine (1)
- Oxidative stress (1)
- p-Hydroxyphenyl-pyruvate (HPP),Phenylpyruvate (1)
- p53 (16)
- PDGF (1)
- PDGF-FGF-VEGF (2)
- Peptides (Endoplasmatic reticulum) (1)
- Phosphatidylcholine (1)
- Phosphatidylinositol (92)
- Phosphatidylinositol 5-phosphate (PI-5-P) (1)
- Phospholipids (2)
- Plasminogen (1)
- Potassium (9)
- PP2A (1)
- PPAR-γ (1)
- Progesterone (6)
- Prostaglandins (12)
- Protein degradation (6)
- Protein L-arginine (1)
- Protein Rad21 (1)
- Pyruvate (2)
- Quinol (1)
- Quorum Sensing (1)
- RAS proteins (7)
- Retinoic acid (1)
- Retinoic Acid (6)
- S-adenosylmethionine (1)
- S-nitrosoglutathione (1)
- S-palmitoylated proteins (1)
- SCF-FLT3-PDGF (2)
- SCF-PDGF-FGF (1)
- SCF-PDGF-VEGF (7)
- SCF-VEGF (2)
- Securin,B type cyclins (1)
- Serotonin (3)
- Serotonin; Dopamine (1)
- Serpin (7)
- Sigma Receptor Substrates (2)
- Smad (3)
- Sodium (1)
- Sonic Hedgehog (2)
- Sphingolipid (1)
- Sphingosine (5)
- Stem cells (iPSC) (3)
- Steroid (Androgens) (3)
- Steroid (Lanosterol 14-α) (4)
- Steroids (2)
- Superoxide (1)
- T-Cell activity (3)
- T-Cell signaling (1)
- T3 (1)
- TGF-β (21)
- Thrombin (7)
- Thrombopoietin (1)
- Thymidylate pathway (2)
- Thyroid-stimulating hormone (thyrotropin) (1)
- TNF-α (9)
- Triglycerides (3)
- Ubiquitin (3)
- UDP (1)
- UDP-glucose (2)
- Unclassified (6)
- Unfolded Protein Response (EIF2 Selective) (3)
- Unfolded Protein Response (Non Selective) (10)
- Unfolded protein response (Non selective) (2)
- VEGF (14)
- Water (1)
- Wnt proteins (7)
- Zinc (1)
- α-Synuclein (1)
- Filter by Action