Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

11 Item(s)

per page
Axon ID Name Description From price
1978 ZM 323881 hydrochloride Inhibitor of VEGFR2 €105.00
1637 Vatalanib VEGFR tyrosine kinase inhibitor €75.00
1717 Tivozanib VEGFR1, 2, and 3 tyrosine kinase inhibitor €99.00
2865 NVP-ACC789 Inhibitor of VEGFR2 €95.00
1963 LY 573636 Anti-tumor agent; causes growth arrest and apoptosis €95.00
1662 CP 547632 VEGFR2 tyrosine kinase inhibitor €105.00
1461 Cediranib VEGFR tyrosine kinase inhibitor €70.00
1864 Brivanib alaninate Prodrug of BMS 540215; Inhibitor of VEGF €105.00
2837 BMS 605541 Potent, selective, orally active, and ATP-competitive VEGFR2 inhibitor  Recently added €90.00
1850 BMS 540215 Inhibitor of VEGFR (subtype 2 and 3 selective) €110.00
2849 Apatinib Inhibitor of VEGFR2 €125.00

11 Item(s)

per page
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