Cell Signaling & Oncology
The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].
Cell Signaling and Oncology products Library
For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.
Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.
 Axon 5051 - Cell signaling and Oncology Library.xls |
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[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1685 | YS 49 | Antiplatelet, antithrombotic | €135.00 | |
| 4009 | XL-765 | Potent and selective PI3K / mTOC inhibitor | Inquire | |
| 4031 | XL-147 | PI3K (α, β, γ, δ) inhibitor | Inquire | |
| 1706 | XL PI3K/mTOR inhibitor | Dual PI3K and mTOR kinase inhibitor | €120.00 | |
| 2951 | XL 388 | Highly potent, selective, ATP-competitive, and orally bioavailable mTOR inhibitor | €125.00 | |
| 3794 | Urolithin A | Inhibitor of the PI3K/AKT/mTOR pathway | €70.00 | |
| 3958 | Uprosertib | Selective and ATP-competitive pan-Akt (PKB) inhibitor | Inquire | |
| 1834 | Torin 2 | mTOR inhibitor | €90.00 | |
| 1833 | Torin 1 | mTOR inhibitor | €90.00 | |
| 1417 | TGX 221 | PI3K inhibitor (p110 β specific) | €70.00 | |
| 3974 | TG100-115 | PI3K P110 ץ/δ isoform-selective inhibitor | Inquire | |
| 1699 | Temsirolimus | mTOR inhibitor | €95.00 | |
| 2927 | Taselisib | PI3K inhibitor (p110 β sparing) | €90.00 | |
| 2387 | SMI 481 | First small-molecule inhibitor (SMI) of the yeast PITP Sec14 | €80.00 | |
| 4075 | Serabelisib | PI3K p110α isoform specific inhibitor | Inquire | |
| 2507 | SC 79 | Unique specific activator of cytosolic Akt; neuroprotective | €75.00 | |
| 1790 | SC 66 | Allosteric Akt inhibitor | €70.00 | |
| 2716 | SAR405 | PIK3C3/Vps34 inhibitor | €90.00 | |
| 2069 | Rapamycin | Specific inhibitor of mTOR; binds to FKBP12 | €85.00 | |
| 1659 | PS 48 | Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1) | €80.00 | |
| 1664 | PS 47 | Negative control of PS 48 as an allosteric PDK1 activator | €90.00 | |
| 1807 | PKI 587 | Dual PI3K and mTOR inhibitor | €90.00 | |
| 4172 | PITCOIN4 | Potent and highly selective PI3KC2α inhibitor | Recently added | €220.00 |
| 3792 | PITCOIN3 | Potent, highly selective and cell-permeable PI3KC2α inhibitor | €210.00 | |
| 1362 | PIK 90 | PI3K inhibitor (p110-α specific) | €85.00 | |
| 1334 | PIK 75 hydrochloride | PI3K inhibitor (p110-α specific) | €70.00 | |
| 3034 | PI-273 | Substrate-competitive, subtype-specific inhibitor of PI4KIIα | €120.00 | |
| 3045 | PI 3065 | PI3K inhibitor (p110 δ specific) | €100.00 | |
| 1380 | PI 103 hydrochloride | PI3K inhibitor (p110 specific) | €60.00 | |
| 1870 | PHT 427 | Inhibitor of Akt and PDPK1 | €75.00 | |