Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1685 YS 49 Antiplatelet, antithrombotic €135.00
1706 XL PI3K/mTOR inhibitor Dual PI3K and mTOR kinase inhibitor €120.00
2951 XL 388 Highly potent, selective, ATP-competitive, and orally bioavailable mTOR inhibitor €125.00
1834 Torin 2 mTOR inhibitor €90.00
1833 Torin 1 mTOR inhibitor €90.00
1417 TGX 221 PI3K inhibitor (p110 β specific) €70.00
1699 Temsirolimus mTOR inhibitor €95.00
2927 Taselisib PI3K inhibitor (p110 β sparing) €90.00
2387 SMI 481 First small-molecule inhibitor (SMI) of the yeast PITP Sec14 €80.00
2507 SC 79 Unique specific activator of cytosolic Akt; neuroprotective €75.00
1790 SC 66 Allosteric Akt inhibitor €70.00
2716 SAR405 PIK3C3/Vps34 inhibitor €90.00
2069 Rapamycin Specific inhibitor of mTOR; binds to FKBP12 €85.00
1659 PS 48 Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1) €80.00
1664 PS 47 Negative control of PS 48 as an allosteric PDK1 activator €90.00

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