Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1621 XMD 8-92 trifluoroacetate BMK1 inhibitor; ERK5 inhibitor €70.00
1846 XMD 8-92 BMK1 inhibitor; ERK5 inhibitor €70.00
1811 VX 745 Inhibitor of p38α MAP kinase €90.00
2520 U 0126 Non-competitive inhibitor of MEK1/2 and protects brain in stroke models €90.00
3282 Takinib Potent and selective TAK1 (MAP3K7) inhibitor €105.00
3183 SR-318 Highly potent and selective type-II p38 α/β inhibitor €120.00
2365 SR 3576 Very potent JNK3 inhibitor with >2800-fold selectivity over p38 €135.00
2519 SP 600125 Selective, reversible, and ATP-competitive JNK inhibitor €70.00
1122 SL 327 MEK1 and MEK2 inhibitor €80.00
2956 Selonsertib Potent, highly selective, orally available, and ATP-competitive ASK1 inhibitor €90.00
1357 SD 169 MAPK inhibitor (p38α specific) €60.00
1671 SCIO 469 MAPK inhibitor (p38 specific) €110.00
1897 SB 747651A Inhibitor of MSK1 €120.00
2444 SB 706504 Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes. €125.00
1465 SB 203580 hydrochloride MAPK inhibitor (p38 specific) €70.00
1363 SB 203580 MAPK inhibitor (p38 specific) €95.00
1364 SB 202190 MAPK inhibitor (p38 specific) €95.00
1837 PH 797804 Inhibitor of p38α MAPK €115.00
2107 PF 431396 Dual FAK(PTK2) and PYK2 inhibitor €80.00
1223 PD 98059 MEK inhibitor €80.00
1368 PD 184352 MEK 1 inhibitor €80.00
1365 PD 169316 MAPK inhibitor (p38 specific) €95.00
1408 PD 0325901 MEK1 and MEK2 inhibitor €50.00
1814 NQDI 1 Inhibitor of apoptosis signal-regulating kinase 1 (ASK1) €115.00
2366 NG 25 trihydrochloride Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) €75.00
1895 LY 2228820 Inhibitor of p38 MAPK €105.00
2361 JNK-IN-8 Remarkably potent and selective covalent inhibitor of JNK €95.00
3059 GW 284543 hydrochloride Selective MEK5 inhibitor €95.00
1761 GSK 1120212 MEK1 and MEK2 inhibitor €70.00
1694 FR 180204 ERK inhibitor; AP-1 inhibitor €95.00

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