Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   


[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2674 YUKA1 Selective inhibitor of KDM5A demethylase €125.00
3995 WT-161 Potent,selective,and bioavailable HDAC6 inhibitor Inquire
2969 WM-1119 Highly potent and selective KAT6A inhibitor €130.00
2411 WDR5-0103 Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL €90.00
3114 Vorinostat HDAC inhibitor €45.00
3722 Valemetostat Inhibitor of Histone Lysine Methyltransferase EZH1/2 Inquire
3592 UNC7145 Negative control of UNC6934 as a chemical probe targeting NSD2-PWWP1 €90.00
3591 UNC6934 Potent and selective chemical probe targeting NSD2-PWWP1 €120.00
1840 UNC0646 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
1889 UNC0638 Inhibitor of G9a (EHMT2)/GLP (EHMT1) €85.00
1841 UNC0631 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
2418 UNC0379 Substrate competitive inhibitor of the H4K20 HMTase SETD8 €125.00
1789 UNC0224 Inhibitor of G9a HMTase €85.00
2518 UF 010 Class I selective HDAC inhibitor that inhibits cancer cell proliferation €60.00
2893 Tucidinostat Orally bioavailable HDAC inhibitor (1, 2, 3, 10 Selective) €95.00
2004 Tubastatin A hydrochloride Potent and selective HDAC6 inhibitor €95.00
3691 Tubacin HDAC6 inhibitor Inquire
2180 TMP 195 HDAC inhibitor (class IIA selective) €110.00
2339 TH 1834 Tip60 histone acetyltransferase inhibitor €140.00
2249 Tenovin 6 Small water soluble p53 activator and SIRT inhibitor €105.00
2008 Tenovin 1 Activates p53 through inhibition of SIRT 1 and 2 €70.00
5008 Stem Cell RG-BIX inhibitor Set Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively €60.00
1875 SRT 1720 tetrahydrochloride Activator of the sirtuin subtype SIRT1 €95.00
4034 SR-4370 Synthetic inhibitor of histone deacetylase (HDAC) Inquire
2864 SP 2509 Potent, reversible, and specific LSD1 inhibitor €80.00
2209 Sodium butyrate Noncompetitive inhibitor of multiple histone deacetylases (HDACs) €50.00
3908 Sirtinol Specific SIRT inhibitor €90.00
2968 SIRT7 inhibitor 97491 Inhibitor of SIRT7 €135.00
2453 SirReal 2 SIRT2 inhibitor with >1000 fold selectivity over SIRT1 and SIRT3 €95.00
3623 SGC-SMARCA-BRDVIII Potent, highly selective and cell-active SMARCA2/4 and PB1(5) bromodomain inhibitor €90.00

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