Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2937 ZT-12-037-01 Specific STK19 inhibitor  Recently added €125.00
2022 Zoniporide hydrochloride Inhibitor of Na+/H+ exchanger isoform 1 (NHE-1) €90.00
1541 ZM 447439 Aurora B inhibitor €85.00
1978 ZM 323881 hydrochloride Inhibitor of VEGFR2 €105.00
2445 ZLN 024 Allosteric activator of AMP-activated protein kinase (AMPK) €90.00
2379 ZLN 005 Selective transcriptional regulator of peroxisome PPAR-γ coactivator-1α (PGC-1α). €45.00
2878 ZL006 Selective inhibitor of the nNOS-PSD-95 interaction €105.00
2239 ZK 216348, (+)- Selective nonsteroidal glucocorticoid receptor (GR) agonist €125.00
1254 Zebularine DNA methyltransferase inhibitor €95.00
2138 ZCL 278 Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction €105.00
2652 ZB716 Steroidal, orally bioavailable SERD €125.00
1248 Zatebradine hydrochloride HCN channel blocker €105.00
2159 Z-VAD-FMK Pan-caspase inhibitor with in vivo activity Inquire
2674 YUKA1 Selective inhibitor of KDM5A demethylase €125.00
1685 YS 49 Antiplatelet, antithrombotic €135.00

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