Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   


[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

18 Item(s)

per page
Axon ID Name Description From price
4093 (Z)-4-Hydroxytamoxifen The more active metabolite of Tamoxifen (SERM; Axon 3252) €110.00
2221 (Z)-Endoxifen The more active (Z)-isomer of Endoxifen (SERM; Axon 2190) €150.00
2051 Bazedoxifene acetate Selective estrogen receptor modulator (SERM) €80.00
1748 Bazedoxifene hydrochloride Selective estrogen receptor modulator (SERM) €70.00
2790 BHPI ER-α antagonist €125.00
3650 Clomiphene citrate Selective estrogen receptor modulator (SERM) €50.00
3320 Diethylstilbestrol Estrogen receptor agonist €50.00
1232 DPN Estrogen (ER-β) agonist €70.00
4095 Elacestrant dihydrochloride Orally bioavailable selective estrogen receptor degrader (SERD) €220.00
2190 Endoxifen Selective estrogen receptor modulator (SERM) €125.00
2707 Endoxifen hydrochloride Selective estrogen receptor modulator (SERM) €130.00
1898 ERB 041 Selective estrogen receptor β (ERβ) agonist €95.00
1926 Estetrol Estrogen receptor agonist (four- to five-fold preference for the Erα) €130.00
1231 PPT ER-α agonist €95.00
3252 Tamoxifen Selective estrogen receptor modulator (SERM) €50.00
2697 WAY-200070 Brain penetrant ERβ-selective agonist €105.00
2337 XCT 790 ERRα inverse agonist and potent mitochondrial uncoupler €120.00
2652 ZB716 Steroidal, orally bioavailable SERD €130.00

18 Item(s)

per page
Please wait...