Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1675 Asoprisnil Progesterone receptor (PR) modulator €120.00
1748 Bazedoxifene hydrochloride Selective estrogen receptor modulator (SERM) €70.00
2645 CC-885 Cereblon (CRBN) modulator with potent anti-tumour activity €145.00
1763 CoPo 22 Modulator of CFTR (δ-F508 Selective) €120.00
2455 CU-T12-9 Selective TLR1/TLR2 agonist that facilitates the TLR1/2 complex formation €120.00
1935 DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) €105.00
2382 ELN 484228 α-Synuclein modulator and potential therapeutic for Parkinson’s disease €75.00
2190 Endoxifen Selective estrogen receptor modulator (SERM) €125.00
2707 Endoxifen hydrochloride Selective estrogen receptor modulator (SERM) €125.00
2221 Endoxifen, (Z)- The more active (Z)-isomer of Endoxifen (SERM; Axon 2190) €155.00
1825 Erastin VDAC2 modulator €95.00
2318 FC 99 hydrochloride Inhibitor of TLR3 expression and inflammatory responses. €95.00
2355 FPH 2 Proliferation inducer of mature human primary hepatocytes €110.00
2327 NEO 212 DNA alkylating agent; chemotherapeutic €110.00
2322 Neuropathiazol Selective inducer of neural differentiation of adult hippocampal neural progenitor cells (NPCs). €135.00

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