Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor €95.00
1424 AS 252424 PI3K inhibitor (p110-γ specific) €85.00
1436 AS 252424 bispotassium salt PI3K inhibitor (p110-γ specific) €95.00
2002 AS 602801 JNK inhibitor, which inhibited JNK1, JNK2 and JNK3 €120.00
2578 ASB14780 Potent, orally available inhibitor of cPLA2α; antiinflammatory drug €120.00
2179 ASK1 Inhibitor 10 Potent, selective, and orally bioavailable ASK1 inhibitor €125.00
2005 ASP 3026 Inhibitor of the oncogenic fusion kinase EML4-ALK €80.00
2787 ASP 9521 Inhibitor of 17 β–hydroxysteroid dehydrogenase type 5 €75.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
2166 AT 13148 dihydrochloride ATP-competitive inhibitor of multi-AGC kinases €85.00
1985 AT 406 Antagonist of Inhibitor of apoptosis proteins (IAPs) €145.00
1539 AT 7519 mesylate CDK inhibitor €80.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
2043 Atorvastatin calcium Inhibitor of HMG-CoA reductase €70.00
1597 Aurora A inhibitor I Aurora A inhibitor €125.00

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