Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

Items 1 to 30 of 1068 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Axon ID Name Description From price
1488 γ-Secretase Inhibitor DBZ γ-Secretase inhibitor (GSI) €80.00
1487 γ-Secretase Inhibitor BZ γ-Secretase inhibitor (GSI) €90.00
3735 ZZW-115 trihydrochloride Potent NUPR1 inhibitor  Recently added €140.00
2937 ZT-12-037-01 Specific STK19 inhibitor €95.00
1839 Zosuquidar trihydrochloride Inhibitor of P-glycoprotein €95.00
2022 Zoniporide hydrochloride Inhibitor of Na+/H+ exchanger isoform 1 (NHE-1) €90.00
1541 ZM 447439 Aurora B inhibitor €85.00
1978 ZM 323881 hydrochloride Inhibitor of VEGFR2 €105.00
2878 ZL006 Selective inhibitor of the nNOS-PSD-95 interaction €105.00
1254 Zebularine DNA methyltransferase inhibitor €95.00
2138 ZCL 278 Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction €105.00
2159 Z-VAD-FMK Pan-caspase inhibitor with in vivo activity Inquire
3206 YW2065 Inhibitor of Wnt/β-catenin signalling; AMPK activator €95.00
2674 YUKA1 Selective inhibitor of KDM5A demethylase €125.00
1685 YS 49 Antiplatelet, antithrombotic €135.00
2675 YMU1 Selective inhibitor of human thymidylate kinase (hTMPK) €110.00
1639 YM 155 Survivin suppressant €95.00
2469 YK 4-279 Inhibitor of ETV1, ERG and interactions of EWS-FLI1 and RNA helicase A €95.00
1683 Y 27632 dihydrochloride ROCK1 and ROCK2 inhibitor €65.00
3535 XY028-140 Potent and selective CDK4/6 inhibitor; PROTAC €120.00
1621 XMD 8-92 trifluoroacetate BMK1 inhibitor; ERK5 inhibitor €70.00
1846 XMD 8-92 BMK1 inhibitor; ERK5 inhibitor €70.00
2762 XMD 8-87 Potent and selective inhibitor of Ack1 tyrosine kinase (also known as TNK2) €95.00
1706 XL PI3K/mTOR inhibitor Dual PI3K and mTOR kinase inhibitor €120.00
2268 XL 413 hydrochloride Potent, selective and orally bioavailable CDC7 inhibitor €120.00
2951 XL 388 Highly potent, selective, ATP-competitive, and orally bioavailable mTOR inhibitor €125.00
2231 XL 019 JAK2 inhibitor €100.00
1527 XAV 939 Tankyrase (TNKS) inhibitor €80.00
2385 WZ 4003 Specific dual inhibitor of NUAK1 (ARK5) and NUAK2 (SNARK) €80.00
1506 WZ 4002 EGFR kinase inhibitor (T790M specific) €70.00

Items 1 to 30 of 1068 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Please wait...