Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

13 Item(s)

per page
Axon ID Name Description From price
2396 RBC 8 Inhibitor of the RAS-like small GTPases RalA and RalB €105.00
3733 MRTX1257 Irreversible covalent inhibitor of KRAS G12C Inquire
3761 MRTX1133 First-in-class, noncovalent, selective & reversible inhibitor of KRASG12D mutant €220.00
2017 ML 210 Chemical probe that selectively kills cells induced to express mutant RAS €115.00
2302 Kobe 0065 HRAS inhibitor €70.00
3768 GDC-6036 Inhibitor of KRAS G12C Inquire
2829 Fendiline hydrochloride KRAS inhibitor; Ca2+ channel blocker (L-type voltage gated) €50.00
2184 CID 1067700 First inhibitor of Rab7 GTPase €125.00
2397 BQU 57 Inhibitor of the RAS-like small GTPases RalA and RalB €125.00
3471 BI-3406 Inhibitor of KRAS/Son of Sevenless 1 (SOS1) interaction Inquire
3053 BAY-293 Potent, selective and cell-active inhibitor of KRAS-SOS1 interaction €140.00
3084 ARS-1620 Potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor €145.00
3575 AMG510 Highly potent, selective, and orally bioavailable KRAS-G12C inhibitor €90.00

13 Item(s)

per page
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