Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2984 WS-383 Highly potent, selective, and cellular active inhibitor of DCN1-UBC12 protein-protein interaction €125.00
1779 WP 1130 Deubiquitinase Inhibitor €95.00
2991 USP7-USP47 inhibitor Selective inhibitor of deubiquitinase USP7 and USP47 €90.00
4121 USP25/28 inhibitor AZ1 Selective dual USP25/USP28 inhibitor €110.00
4089 Usp22i-S02 First potent Usp22-specific inhibitor €90.00
2333 TCID Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1 €80.00
3797 TAK-981 oxalate Inhibitor of SUMOylation €110.00
3608 STD1T Inhibitor of the deubiquitinase USP2a €160.00
2512 Spautin 1 Inhibitor of USP10 and USP13 and Beclin1 related autophagy €95.00
1904 SMER 3 Inhibitor of an SCF family E3 Ubiquitin ligase €90.00
3210 RA375 Potent RPN13 inhibitor €180.00
1953 PRT 4165 E3 Ubiquitin ligase Bmi1/Ring1A inhibitor €70.00
1906 P 22077 Inhibitor of deubiquitinase USP7 and USP47 €95.00
2011 P 005091 Inhibitor of deubiquitinase USP7 and USP47 €95.00
3849 Oprozomib Orally active and irreversible inhibitor of 20S proteasome Inquire
2199 ONX 0914 Selective inhibitor of LMP7 subunit of the immunoproteasome. €70.00
2228 NSC 687852 Inhibitor of 19S regulatory-particle–associated deubiquitinases (DUBs: UCHL5 and USP14) €90.00
2557 MLN9708 Citrate prodrug of MLN2238, selective and reversible 20S proteasome inhibitor €95.00
3829 MLN7243 Cell permeable small molecule inhibitor targeting ubiquitin-activating enzymes (UAE, also known as E1 enzymes) Inquire
2556 MLN2238 Selective and reversible 20S proteasome inhibitor €85.00
2678 ML364 Inhibitor of the deubiquitinase USP2 €125.00
3109 ML-792 Potent and selective inhibitor of SUMO-activating enzyme (SAE) €145.00
2995 ML 367 Inhibitor of ATAD5 stabilization €125.00
2309 ML 323 Selective, reversible and potent inhibitor of the USP1–UAF1 deubiquitinase complex €95.00
1869 MG 132 Inhibitor of 26S proteasome €80.00
3724 M-3258 Selective inhibitor of LMP7 subunit of the immunoproteasome Inquire
2449 LDN 57444 Reversible, competitive inhibitor of UCH-L1 deubiquitinase €95.00
3770 KSQ-2479 An allosteric, first-in-class USP1 (Ubiquitin Specific Protease 1) inhibitor Inquire
3426 IU1-47 Potent and selective inhibitor deubiquitinase USP14 €80.00
3732 HBX 41,108 Inhibitor of deubiquitinase USP7 €90.00

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