Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1613 MDV 3100 Androgen receptor (AR) antagonist €70.00
1502 Mifepristone Progesterone receptor (PR) antagonist €45.00
1480 MK 0524 sodium salt PGD2 receptor DP1 antagonist €125.00
2321 ML 154 Competitive, selective, and brain penetrant NPS receptor antagonist €120.00
1862 MRS 2578 P2Y6 nucleotide receptor antagonist €90.00
1938 MRT 10 Smoothened (SMO) receptor antagonist €125.00
1205 Naloxonazine dihydrochloride Opioid antagonist €75.00
1619 NVP-LDE225 Smoothened (SMO) antagonist €85.00
1913 OC 000459 Selective DP2 (CRTH2) antagonist €90.00
1512 ONO 8711 dicyclohexyl amine salt PGE1 receptor EP1 antagonist €120.00
1958 P2Y14 Antagonist Prodrug 7j hydrochloride Prodrug of P2Y14 receptor antagonist €125.00
2024 PF 04418948 Prostaglandin EP2 receptor antagonist €95.00
2027 PF 5274857 hydrochloride Smoothened (SMO) antagonist €95.00
2620 Quininib Antagonist of the cysteinyl leukotriene receptor (CysLT1 and -2) €95.00
2902 QX77 Chaperone-mediated autophagy (CMA) activator €120.00

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