Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1620 WZ 811 CXCR4 antagonist €80.00
2424 WAY 100635 maleate 5-HT1A antagonist with D4 agonistic properties €125.00
2163 UNC 669 Antagonist of KMe reader protein L3MBTL1 and 3 €70.00
1994 UNC 1215 Antagonist of L3MBTL3 methyllysine reader domain €85.00
2993 UNBS5162 Pan-antagonist of CXCL chemokine expression €95.00
1270 T 98475 GnRH or LHRH antagonist Inquire
3058 STING inhibitor C-178 Highly potent and selective STING antagonist €90.00
2923 STING inhibitor C-176 Highly potent and selective STING antagonist €90.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00
2807 SPA70 Potent and selective human pregnane X receptor (hPXR) antagonist €125.00
1447 Seratrodast Thromboxane A2 antagonist €85.00
1387 SD 208 TGF-βR 1 inhibitor €50.00
1275 SCH 79797 dihydrochloride PAR1 antagonist €130.00
1755 SCH 530348 PAR1 antagonist €150.00
2192 SB 674042 Nonpeptide OX1 selective antagonist with >100 fold selectivity over the OX2 receptor. €99.00
2285 SB 525334 Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor €105.00
2197 SB 505124 Selective inhibitor of TGF-β type I receptors ALK4 and ALK5 €95.00
1661 SB 431542 TGF-βR1 inhibitor; ALK inhibitor €70.00
2095 SB 334867 First selective orexin 1 (OX1) antagonist €90.00
2593 SB 332235 Nonpeptide CXCR2 antagonist exhibiting significant anti-inflammatory effects €105.00
2183 SB 269970 hydrochloride Potent and selective 5-HT7 antagonist €110.00
1559 SB 265610 CXCR2 antagonist €120.00
1605 S 5751 PGD2 receptor DP1 antagonist €115.00
1680 RU 58841 Androgen receptor (AR) antagonist €80.00
1532 RD 162 Androgen receptor (AR) antagonist €125.00
2902 QX77 Chaperone-mediated autophagy (CMA) activator €120.00
2620 Quininib Antagonist of the cysteinyl leukotriene receptor (CysLT1 and -2) €95.00
3151 QND7 nAChR antagonist (α7 sub-unit selective) €130.00
3420 PPTN hydrochloride High affinity and specific P2Y14 receptor antagonist €130.00
2027 PF 5274857 hydrochloride Smoothened (SMO) antagonist €95.00

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