Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

16 Item(s)

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Axon ID Name Description From price
1387 SD 208 TGF-βR 1 inhibitor €50.00
2285 SB 525334 Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor €105.00
2197 SB 505124 Selective inhibitor of TGF-β type I receptors ALK4 and ALK5 €95.00
1661 SB 431542 TGF-βR1 inhibitor; ALK inhibitor €70.00
3404 LY-364947 Potent, selective and ATP-competitive TGF-βR 1 inhibitor €90.00
3892 LY-3200882 TGF-βR 1 inhibitor Inquire
1491 LY 2157299 TGF-βR2 inhibitor €60.00
2201 LDN 212854 trihydrochloride Potent ALK2-biased BMP type I receptor kinase inhibitor €110.00
3552 LDN 212854 Potent ALK2-biased BMP type I receptor kinase inhibitor €110.00
1509 LDN 193189 hydrochloride Highly potent small molecule inhibitor of BMP type I receptors ALK2, ALK3, and ALK6 €65.00
2323 ITD 1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis €105.00
2236 IN 1130 TGF-βR 1 inhibitor €95.00
1832 GW 788388 TGF-βR 1 inhibitor €50.00
1421 A 83-01 TGF-βR 1 inhibitor; ALK 5 inhibitor €70.00
1744 A 77-01 TGF-βR 1 inhibitor; ALK 5 inhibitor €80.00
2467 (+)-ITD-1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis €165.00

16 Item(s)

per page
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