Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2467 (+)-ITD-1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis €165.00
1744 A 77-01 TGF-βR 1 inhibitor; ALK 5 inhibitor €80.00
2182 A 804598 Potent and selective P2X7 antagonist €125.00
1421 A 83-01 TGF-βR 1 inhibitor; ALK 5 inhibitor €70.00
1179 A1B1 hydrochloride CCR1 antagonist €125.00
2062 Alprostadil Prostaglandin EP (1-4) receptor antagonist €125.00
1738 AMD 3100 CXCR4 antagonist €85.00
1930 AMD 3465 hexahydrobromide Potent and selective CXCR4 antagonist €85.00
2468 ANA 12 Selective TrkB antagonist with anxiolytic and antidepressant activity in mice €90.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00
1979 ARN 509 Antagonist of androgen receptor (AR) €95.00
2145 AZD 1981 Selective CRTH2 (aka DP2) antagonist €90.00
2842 AZD 2098 Potent, selective and bioavailable CCR4 receptor antagonist €125.00
2255 AZD 8797 Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1) €120.00
1700 Bexarotene Retinoid X Receptor antagonist €65.00
2790 BHPI ER-α antagonist €125.00
1940 BI 6015 Potent hepatocyte nuclear factor 4α (HNF4α) antagonist €120.00
3295 BIA TMBIM6 antagonist €120.00
3313 Bicalutamide Androgen receptor (AR) antagonist €50.00
2356 BMS 833923 Oral antagonist of the Hedgehog signaling component Smoothened (SMO) €75.00
2523 BX 430 Allosteric antagonist of human P2X4 receptor channels €105.00
2082 BX 471 Selective CCR1 receptor antagonist €105.00
2827 C-DIM8 Nur77 antagonist €95.00
1732 CaSR antagonist 18c Calcium-sensing receptor (CaSR) antagonist €130.00
2665 Cenicriviroc Oral CCR5-antagonist for treatment of HIV infection €160.00
3085 CPI-444 Potent, selective and oral adenosine A2A antagonist €85.00
1800 CXCR3 Antagonist 6c CXCR3 antagonist €135.00
2738 CysLT1 Antagonist Q8 Antagonist of the cysteinyl leukotriene receptor 1 (CysLT1) €95.00
2561 DY 268 Highly potent FXR antagonist with a promising in vitro profile €120.00
2030 E 5555 hydrobromide Potent and orally active PAR1 antagonist €115.00

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