Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1907 GLP-1R agonist DMB GLP-1 Receptor (GLP1R) Agonist €99.00
2013 GW 9508 GPR40 receptor agonist (FFA1) €85.00
2533 Hydroxypioglitazone Active metabolite of Pioglitazone (M-IV), a PPARγ agonist €235.00
2406 IMM 01 Small-molecule agonist of mammalian Diaphanous (mDia)-related formins €95.00
2065 Levonorgestrel Progesterone receptor (PR) agonist €50.00
2066 Methylprednisolone Synthetic glucocorticoid drug; anti-inflammatory €65.00
2402 MHY 908 Dual PPARα/γ agonist, and potent inhibitor of mushroom tyrosinase €95.00
1750 MIBG hemisulfate Radiopharmaceutical; Noradrenaline analogue €115.00
2783 Motolimod Highly potent and selective TLR8 agonist €145.00
2408 NRX 194204 Highly potent and specific RXR agonist devoid of any RAR activity €105.00
2085 Org OD 02-0 Selective agonist of membrane progesterone receptor (mPR) €120.00
1272 PB 28 dihydrochloride Sigma-2 agonist €75.00
1231 PPT ER-α agonist €95.00
1690 Purmorphamine Hedgehog signaling pathway activator €105.00
2152 PX 20350 Potent farnesoid X receptor (FXR) agonist €105.00

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