Cell Signaling & Oncology
The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].
Cell Signaling and Oncology products Library
For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.
Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.
Axon 5051 - Cell signaling and Oncology Library.xls | |
[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2337 | XCT 790 | ERRα inverse agonist and potent mitochondrial uncoupler | €120.00 | |
2697 | WAY-200070 | Brain penetrant ERβ-selective agonist | €105.00 | |
1749 | WAY 362450 | Farnesoid X receptor (FXR) agonist | €125.00 | |
2075 | TUG 891 | Potent and selective GPR120 (FFA4) agonist | €110.00 | |
2516 | Tacalcitol | Vitamine D receptor (VDR) agonist with antitumor activity | €165.00 | |
3673 | STING activator C53 | Highly potent STING activator | €120.00 | |
3727 | SR11237 | Selective retinoid X Receptor agonist | €120.00 | |
3336 | SR-717 lithium | Non-nucleotide STING agonist | €90.00 | |
2598 | SR 9243 | LXR inverse agonist inhibiting the Warburg effect and lipogenesis in cancer cells | €85.00 | |
3551 | Sandalore | Selective agonist of the olfactory receptor OR2AT4; Synthetic odorant | €120.00 | |
2443 | Rosiglitazone | PPARγ agonist; antidiabetic drug and stem cell differentiator | €95.00 | |
2152 | PX 20350 | Potent farnesoid X receptor (FXR) agonist | €105.00 | |
1690 | Purmorphamine | Hedgehog signaling pathway activator | €120.00 | |
3269 | PSB-KD107 | Selective agonist for GPR18 | €140.00 | |
1231 | PPT | ER-α agonist | €95.00 | |
1272 | PB28 dihydrochloride | Sigma-2 agonist | €85.00 | |
2085 | Org OD 02-0 | Selective agonist of membrane progesterone receptor (mPR) | €120.00 | |
2408 | NRX 194204 | Highly potent and specific RXR agonist devoid of any RAR activity | €110.00 | |
3298 | MSA-2 | Selective and orally available non-nucleotide STING agonist | €90.00 | |
2783 | Motolimod | Highly potent and selective TLR8 agonist | €145.00 | |
1750 | MIBG hemisulfate | Radiopharmaceutical; Noradrenaline analogue | €115.00 | |
2402 | MHY 908 | Dual PPARα/γ agonist, and potent inhibitor of mushroom tyrosinase | €95.00 | |
2066 | Methylprednisolone | Synthetic glucocorticoid drug; anti-inflammatory | €65.00 | |
3740 | LYC-55716 | Potent RORγ agonist | Inquire | |
3728 | LHC-165 | Agonist (activator) of Toll-like Receptor 7 | Inquire | |
2065 | Levonorgestrel | Progesterone receptor (PR) agonist | €50.00 | |
2406 | IMM 01 | Small-molecule agonist of mammalian Diaphanous (mDia)-related formins | €95.00 | |
3107 | Imiquimod | TLR7/TLR8 agonist | €60.00 | |
2533 | Hydroxypioglitazone | Active metabolite of Pioglitazone (M-IV), a PPARγ agonist | €180.00 | |
2013 | GW 9508 | GPR40 receptor agonist (FFA1) | €85.00 |