Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

Items 1 to 15 of 37 total

per page
Page:
  1. 1
  2. 2
  3. 3
Axon ID Name Description From price
2275 AdipoRon Orally active small-molecule AdipoR agonist €80.00
2948 AM 580 RAR-α agonist  Recently added €95.00
2405 AMG 837 calcium salt Orally bioavailable partial agonist of GPR40 (FFA1) €110.00
2259 BETP Positive allosteric modulator (PAM) at the GLP-1 receptor €105.00
2335 Brexpiprazole dihydrochloride Drug candidate with high affinity for 5-HT1A, 5-HT2A, D2L, α1B, and α2C-adrenergic receptors €135.00
1676 BXL 628 Vitamin D receptor (VDR) agonist €165.00
2828 C-DIM5 Nur77 agonist €95.00
1950 CDDO A potent multifunctional anti-tumor agent. PPAR-γ agonist €110.00
1426 Ciclesonide Glucocorticoid €65.00
1746 Doxercalciferol Vitamin D2 analog, VDR agonist €105.00
1232 DPN Estrogen (ER-β) agonist €70.00
2727 Elafibranor Dual PPARα/δ agonist €90.00
1872 Eltrombopag Thrombopoietin receptor (TpoR or c-MPL) agonist €95.00
1898 ERB 041 Selective estrogen receptor β (ERβ) agonist €95.00
1926 Estetrol Estrogen receptor agonist, (four- to five-fold preference for the Erα) €95.00

Items 1 to 15 of 37 total

per page
Page:
  1. 1
  2. 2
  3. 3
Please wait...