Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
2445 ZLN 024 Allosteric activator of AMP-activated protein kinase (AMPK) €90.00
2120 Wnt agonist 1 Wnt/β-catenin signaling pathway agonist or activator €90.00
2300 TIC10 active isomer Small molecule that transcriptionally induces TRAIL €125.00
2240 TEPP-46 Potent activator of recombinant PKM2 with little or no activity versus PKM1, PKL and PKR. €90.00
1875 SRT 1720 tetrahydrochloride Activator of the sirtuin subtype SIRT1 €95.00
2084 SKL 2001 Wnt/β-catenin signaling pathway agonist or activator €90.00
2244 SCH 529074 Small molecule activator of mutant p53. €120.00
2507 SC 79 Unique specific activator of cytosolic Akt; neuroprotective €75.00
3480 PY-60 Specific YAP activator targeting ANXA2 €150.00
1659 PS 48 Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1) €80.00
1743 PAC 1 Procaspase activating compound 1 €80.00
3581 ONC212 TRAIL inducer; Selective GPR132 agonist €110.00
2497 Omaveloxolone Triterpenoid activator of NRF2 and inhibitor of NF-κB €90.00
2564 NSC 59984 Activator of p53 that restores WT p53 signaling via p73 activation €95.00
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €95.00
2955 NSC 228155 EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction €75.00
2565 N106 Activator of E1 ligase mediated SERCA2a SUMOylation €95.00
1941 MLR 1023 Selective allosteric activator of Lyn kinase €95.00
2703 ML346 Hsp70 activator €125.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €130.00
2149 Mitapivat

Activator of pyruvate kinase isoenzyme M2 (PKM2)

€125.00
2425 MHY 1485 mTOR activator with an inhibitory effect on autophagy €70.00
2484 K6PC-5 SphK1 (or SK1) activator that increases sphingosine-1-phosphate production €105.00
2021 HL 010183 Metformin derivative; AMPK activator €135.00
3262 HEI3090 Positive modulator of the P2X7 receptor €130.00
2264 Forskolin Activator of adenylate cyclase. Naturally occurring labdane diterpene €90.00
2841 COTI-2 Reactivator of mutant p53 €125.00
1835 CK 1827452 Cardiac specific myosin ATPase activator €115.00
2575 C-DIM12 Nurr1 activator that stimulates apoptosis in bladder cancer cells €85.00
3431 BTSA1 Potent activator of proapoptotic BAX €110.00

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