Cell Signaling & Oncology

Axon Ligands™ for Cell Signaling & Oncology Research

The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

Cell Signaling and Oncology products Library

For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

Axon Ligands™ for Epigenetic research   Axon 5051 - Cell signaling and Oncology Library.xls                   

 

[1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
[2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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Axon ID Name Description From price
1466 A 769662 AMPK activator €85.00
2389 AICAR Potent AMPK activator and inducer of differentiation of NSCs €45.00
2551 Alda 1 Small molecule activator of ALDH2 €65.00
2006 Apoptosis Activator 2 A cell-permeable apoptosis activator €75.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €105.00
2172 BAY 58-2667 hydrochloride Soluble, potent nitric oxide-independent guanylyl cyclase (sGC) activator €125.00
2575 C-DIM12 Nurr1 activator that stimulates apoptosis in bladder cancer cells €85.00
1835 CK 1827452 Cardiac specific myosin ATPase activator €115.00
2841 COTI-2 Reactivator of mutant p53 €125.00
2089 Dihydroxyflavone, 7,8- Tyrosine kinase receptor B (TrkB) agonist €55.00
2264 Forskolin Activator of adenylate cyclase. Naturally occurring labdane diterpene €90.00
2021 HL 010183 Metformin derivative; AMPK activator €135.00
2484 K6PC-5 SphK1 (or SK1) activator that increases sphingosine-1-phosphate production €105.00
2425 MHY 1485 mTOR activator with an inhibitory effect on autophagy €70.00
2149 Mitapivat

Activator of pyruvate kinase isoenzyme M2 (PKM2)

€125.00

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