Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
1593 ABT 888 PARP inhibitor €55.00
2888 ABT 888 dihydrochloride PARP inhibitor €95.00
1529 AG 014699 PARP1 inhibitor €75.00
1496 Aminobenzamide, 3- Competitive small molecule inhibitor of PARP €45.00
2839 AS 1842856 Inhibitor of the Forkhead box protein O1 (FOXO1) €95.00
1464 AZD 2281 PARP inhibitor €55.00
2241 AZD 2461 PARP inhibitor with poor P-glycoprotein substrate qualities €105.00
1399 AZD 7762 hydrochloride CHK inhibitor €60.00
2462 BMH 21 Inhibitor of RNA Polymerase I (RNAP1) €95.00
1636 CHIR 124 CHK1 inhibitor €65.00
1495 CP 466722 ATM inhibitor €80.00
2173 CX 5461 Inhibitor of RNA Polymerase I (RNAP1) €135.00
1268 DR 2313 PARP inhibitor €90.00
2975 Fatostatin hydrobromide Specific inhibitor of SREBP cleavage-activating protein (SCAP) €90.00

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