Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

10 Item(s)

per page
Axon ID Name Description From price
2351 EHop 016 Rac GTPase inhibitor specific for Rac1 and Rac3 €85.00
2406 IMM 01 Small-molecule agonist of mammalian Diaphanous (mDia)-related formins €95.00
2777 MBQ-167 Dual Rac and Cdc42 inhibitor €105.00
2658 MPT0B098 Microtubule inhibitor that suppresses JAK2/STAT3 signaling €105.00
1578 NSC 23766 Rac1 inhibitor €110.00
3083 PVHD121 Microtubule inhibitor  Recently added €120.00
2398 Suprafenacine Destabilizer of microtubules that causes cell cycle arrest in the G2/M phase €110.00
1804 Wiskostatin Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) €105.00
2816 WX-132-18B Tubulin-polymerization inhibitor targeting the colchicine site €115.00
2138 ZCL 278 Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction €105.00

10 Item(s)

per page
Please wait...