Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

5 Item(s)

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Axon ID Name Description From price
2407 BTB 1 The first small molecule reversible inhibitor of the mitotic motor protein Kif18A €70.00
2439 Dimethylenastron Specific potent and cell-permeable inhibitor of Eg5 (KSP) €105.00
2446 Ispinesib First potent, highly specific small-molecule inhibitor of human KSP €120.00
2901 KHS101 hydrochloride Selective, brain-penetrable inducer of neuronal differentiation and TACC3 inhibitor €95.00
2474 SPL-B Inhibitor of TACC3 that inhibits nucleation of centrosome microtubules €125.00

5 Item(s)

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