Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
2397 BQU 57 Inhibitor of the RAS-like small GTPases RalA and RalB €125.00
2184 CID 1067700 First inhibitor of Rab7 GTPase €125.00
2302 Kobe 0065 HRAS inhibitor €70.00
2017 ML 210 Chemical probe that selectively kills cells induced to express mutant RAS €115.00
2396 RBC 8 Inhibitor of the RAS-like small GTPases RalA and RalB €125.00

5 Item(s)

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