Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

4 Item(s)

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Axon ID Name Description From price
1642 AZ 3146 MPS1 kinase inhibitor €90.00
2358 Mps1-IN-2 Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 €95.00
1629 Reversine MPS1 kinase inhibitor €85.00
2755 TC Mps1 12 Potent and selective inhibitor of MPS1 kinase €115.00

4 Item(s)

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