Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

8 Item(s)

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Axon ID Name Description From price
1129 BI 2536 PLK1 inhibitor €60.00
1473 BI 6727 PLK1 Inhibitor €90.00
1688 GSK 461364 PLK1 inhibitor €105.00
1625 GSK 461364 analogue I PLK1 Inhibitor €110.00
1626 GSK 461364 analogue II PLK1 Inhibitor €110.00
1131 GW 843682X PLK1 and PLK3 inhibitor €75.00
1910 MLN 0905 PLK1 inhibitor €95.00
2950 Rigosertib sodium Non-ATP-competitive PLK1 inhibitor €95.00

8 Item(s)

per page
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