Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
1783 AMG 900 Aurora inhibitor (non-specific) €115.00
1836 CCT 137690 Aurora inhibitor (non-specific) €115.00
2023 PF 03814735 ATP-competitive inhibitor of aurora kinase A and B €120.00
2906 SNS 314 mesylate Potent and selective Aurora inhibitor (non-specific) €90.00
1540 VX 680 Aurora inhibitor (non-specific) €60.00

5 Item(s)

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