Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

7 Item(s)

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Axon ID Name Description From price
2449 LDN 57444 Reversible, competitive inhibitor of UCH-L1 deubiquitinase €95.00
2309 ML 323 Selective, reversible and potent inhibitor of the USP1–UAF1 deubiquitinase complex €95.00
2678 ML364 Inhibitor of the deubiquitinase USP2 €125.00
2228 NSC 687852 Inhibitor of 19S regulatory-particle–associated deubiquitinases (DUBs: UCHL5 and USP14) €90.00
1906 P 22077 Inhibitor of deubiquitinase USP7 and USP47 €95.00
2512 Spautin 1 Inhibitor of USP10 and USP13 and Beclin1 related autophagy €95.00
2333 TCID Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1 €80.00

7 Item(s)

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