Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

10 Item(s)

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Axon ID Name Description From price
2141 ABT 199 Potent, orally bioavailable BCL-2-selective inhibitor €120.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €105.00
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
2879 CP 31398 Stabilizer of p53 and inducer of apoptosis  Recently added €95.00
2496 Dimethylcelecoxib, 2,5- Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity €75.00
2007 HA 14-1 Bcl-2 inhibitor and apoptosis inducer of tumor cells €75.00
2823 ML 311 Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim €95.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
1701 Shz-1 Stem cell differentiating agent; Nkx2.5 inducer €95.00

10 Item(s)

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