Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

8 Item(s)

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Axon ID Name Description From price
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
2795 AZD 1208 Pim kinase inhibitor €70.00
2305 CX 6258 hydrochloride Pim kinase inhibitor €99.00
2574 Defactinib Orally available second generation inhibitor of FAK and PYK2 €95.00
2459 PND 1186 Orally active dual FAK/PYK2 inhibitor triggering cell apoptosis in tumor cells €105.00
2920 Poziotinib Irreversible pan-HER inhibitor €95.00
1633 SGI 1776 free base Pim kinase inhibitor €95.00
1923 SMI 4a ATP-competitive and selective inhibitor of Pim kinases €75.00

8 Item(s)

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