Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

8 Item(s)

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Axon ID Name Description From price
2540 Akt Inhibitor VIII Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) €95.00
2994 GNE 317 Brain-penetrant PI3K inhibitor (p110-α specific) €85.00
2460 GSK 2110183 hydrochloride Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases €105.00
1472 KU 0063794 mTOR inhibitor €60.00
3046 MRT 67307 TBK1 and IKKϵ inhibitor €125.00
2029 NVP-BGT226 Orally active dual PI3K/mTOR inhibitor €120.00
1855 PF 04691502 PI3K and mTOR tyrosine kinase inhibitor €90.00
2507 SC 79 Unique specific activator of cytosolic Akt; neuroprotective €75.00

8 Item(s)

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