Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

11 Item(s)

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Axon ID Name Description From price
2639 AMG 232 Potent, selective, and orally bioavailable MDM2-p53 inhibitor €115.00
1643 HLI 373 HDM2 inhibitor €95.00
1538 JNJ 26854165 HDM2 inhibitor €105.00
1586 JNJ 26854165 dihydrochloride HDM2 inhibitor €105.00
1585 Nutlin-3 MDM2 inhibitor (p53 specific) €95.00
1880 Nutlin-3a Inhibitor of MDM2 €95.00
1881 Nutlin-3b Less potent (+)-enantiomer of Nutlin-3 €90.00
2009 RITA Activates p53 through inhibition of MDM2 €105.00
2741 SAR405838 MDM2-p53 inhibitor €125.00
2164 SJ 172550 Small molecule inhibitor of MDMX €95.00
2437 SP 141 Specific MDM2 inhibitor with therapeutic effects in breast cancer models €120.00

11 Item(s)

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