Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
1541 ZM 447439 Aurora B inhibitor €85.00
2138 ZCL 278 Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction €105.00
1639 YM 155 Survivin suppressant €95.00
2268 XL 413 hydrochloride Potent, selective and orally bioavailable CDC7 inhibitor €120.00
1527 XAV 939 Tankyrase (TNKS) inhibitor €80.00
2816 WX-132-18B Tubulin-polymerization inhibitor targeting the colchicine site €115.00
1804 Wiskostatin Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) €105.00
2411 WDR5-0103 Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL €90.00
2325 WAY 316606 hydrochloride Potent inhibitor of sFRP-1 that stimulates Wnt signaling €85.00
1540 VX 680 Aurora inhibitor (non-specific) €60.00
1608 VER 155008 Hsp70 inhibitor €95.00
2452 VE 822 Selective ATR inhibitor that decreases survival of pancreatic cancer cells €110.00
1893 VE 821 Inhibitor of the DNA damage response kinase ATR €95.00
2369 UPF 1069 PARP-2 inhibitor with >26 fold selectivity over PARP1 €75.00
1840 UNC 0646 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00

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