Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.

[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

7 Item(s)

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Axon ID Name Description From price
2438 Cuspin-1 Upregulator of the Survival of Motor Neuron protein (SMN) by Ras signaling activation €95.00
1825 Erastin VDAC2 modulator €90.00
2355 FPH 2 Proliferation inducer of mature human primary hepatocytes €110.00
2327 NEO 212 DNA alkylating agent; chemotherapeutic €110.00
2322 Neuropathiazol Selective inducer of neural differentiation of adult hippocampal neural progenitor cells (NPCs). €135.00
2487 Silibinin Natural flavonolignan, cytoprotectant, antioxidant, and antihepatotoxic agent €40.00
2326 Temozolomide DNA methylating agent; apoptosis inducer €50.00

7 Item(s)

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