Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

6 Item(s)

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Axon ID Name Description From price
2828 C-DIM5 Nur77 agonist €95.00
2533 Hydroxypioglitazone Active metabolite of Pioglitazone (M-IV), a PPARγ agonist €235.00
2406 IMM 01 Small-molecule agonist of mammalian Diaphanous (mDia)-related formins €95.00
2408 NRX 194204 Highly potent and specific RXR agonist devoid of any RAR activity €105.00
2443 Rosiglitazone PPARγ agonist; antidiabetic drug and stem cell differentiator €95.00
2943 SRI-011381 hydrochloride TGF-β signaling agonist  Recently added €125.00

6 Item(s)

per page
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