Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

9 Item(s)

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Axon ID Name Description From price
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
2378 Kartogenin Promotor of chondrocyte differentiation from primary human MSCs €75.00
2641 ML334 Activator of NRF2 by inhibition of Keap1-NRF2 interactions €120.00
2703 ML346 Hsp70 activator €125.00
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €95.00
2564 NSC 59984 Activator of p53 that restores WT p53 signaling via p73 activation €95.00
2497 RTA 408 Triterpenoid activator of NRF2 and inhibitor of NF-κB €110.00
2507 SC 79 Unique specific activator of cytosolic Akt; neuroprotective €75.00
2244 SCH 529074 Small molecule activator of mutant p53. €100.00

9 Item(s)

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