Cardiovascular

The circulatory system is a vast network of organs and vessels that is responsible for the flow of blood, nutrients, oxygen and other gases, and hormones to and from cells. The system consists of three independent systems that work together: the heart (cardiovascular), lungs (pulmonary), and arteries, veins, coronary and portal vessels (systemic). Together, the heart, blood, and blood vessels make up the cardiovascular component of the circulatory system. It includes the pulmonary circulation, a "loop" through the lungs where blood is oxygenated. It also incorporates the systemic circulation, which runs through the rest of the body to provide oxygenated blood. 
Because of its vastness and critical nature, the circulatory system is one of the systems of the body most prone to disease. Disorders of this system are the leading cause of death among adults in the majority of countries world-wide, arteriosclerosis being one of  the most common diseases. It is characterized by  fatty deposits in the arteries that cause the walls to stiffen and thicken the walls, and may result in restricted blood flow and ischemia. This may result in symptoms such as angina and dyspnea, necrosis, and ultimately in heart attack or stroke. Hypertension, another circulatory is disease, causes the heart to work harder and can lead to complications as a heart attack, a stroke, or kidney failure. Abnormal blood lipid levels, that is high total cholesterol, high levels of triglycerides, high levels of low-density lipoprotein or low levels of high-density lipoprotein (HDL) cholesterol all increase the risk of heart disease and stroke, and are of particular interest of modern research. 
Besides changing food intake habits of patients suffering from cardiovascular diseases, in combination with the stimulation to increase physical exercise, special medication may also modify a patients blood lipid profile and prevent the person from developing life threatening circulatory diseases.

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Axon ID Name Description From price
3047 BI-6C9 Inhibitor of BID protein €145.00
3458 Bisoprolol fumarate Potent and cardioselective β1 antagonist  Recently added €50.00
1112 BMS 204352 Maxi K+ channel opener €105.00
2506 BMS 303141 Cell-permeable ATP-citrate lyase (ACL) inhibitor €90.00
2798 BPKDi PKD inhibitor €155.00
2931 BRD0705 First-in-class, paralog selective GSK3α inhibitor €210.00
3153 BRD5648 Negative control compound of BRD0705 as a GSK3α inhibitor €210.00
1157 Bromobuterol β2 agonist €85.00
2662 CAIX Inhibitor S4 Carbonic anhydrase (CA) IX/XII inhibitor €90.00
3104 Candesartan cilexetil Potent and highly specific AT2 receptor antagonist €50.00
2550 Cardiogenol C hydrochloride Stem cell differentiator; inducer of the differentiation of ESCs to cardiomyocytes €90.00
3456 Carvedilol β- and α1 adrenoceptor receptor antagonist  Recently added €50.00
3393 CB096 Selective RAN inhibitor  Recently added €110.00
2684 CDN1163 Allosteric Activator of SERCA2b €90.00
2929 CE3F4 Inhibitor of EPAC1 €95.00

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