Cardiovascular

The circulatory system is a vast network of organs and vessels that is responsible for the flow of blood, nutrients, oxygen and other gases, and hormones to and from cells. The system consists of three independent systems that work together: the heart (cardiovascular), lungs (pulmonary), and arteries, veins, coronary and portal vessels (systemic). Together, the heart, blood, and blood vessels make up the cardiovascular component of the circulatory system. It includes the pulmonary circulation, a "loop" through the lungs where blood is oxygenated. It also incorporates the systemic circulation, which runs through the rest of the body to provide oxygenated blood. 
Because of its vastness and critical nature, the circulatory system is one of the systems of the body most prone to disease. Disorders of this system are the leading cause of death among adults in the majority of countries world-wide, arteriosclerosis being one of  the most common diseases. It is characterized by  fatty deposits in the arteries that cause the walls to stiffen and thicken the walls, and may result in restricted blood flow and ischemia. This may result in symptoms such as angina and dyspnea, necrosis, and ultimately in heart attack or stroke. Hypertension, another circulatory is disease, causes the heart to work harder and can lead to complications as a heart attack, a stroke, or kidney failure. Abnormal blood lipid levels, that is high total cholesterol, high levels of triglycerides, high levels of low-density lipoprotein or low levels of high-density lipoprotein (HDL) cholesterol all increase the risk of heart disease and stroke, and are of particular interest of modern research. 
Besides changing food intake habits of patients suffering from cardiovascular diseases, in combination with the stimulation to increase physical exercise, special medication may also modify a patients blood lipid profile and prevent the person from developing life threatening circulatory diseases.

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Axon ID Name Description From price
2830 (R)-CE3F4 Potent inhibitor of EPAC1 €105.00
2929 CE3F4 Inhibitor of EPAC1 €95.00
2847 ESI-08 Selective EPAC antagonist €145.00
3326 HJC0197 Potent EPAC antagonist €90.00
2730 HJC0350 Highly potent and selective EPAC2 antagonist €95.00
3314 Milrinone PDE3 inhibitor €80.00
1168 Olprinone hydrochloride PDE3 inhibitor €119.00
1482 Parogrelil PDE3 inhibitor €120.00
3179 Pentoxifylline Non-specific inhibitor of cAMP phosphodiesterases €40.00
2352 Roflumilast First specific PDE4 inhibitor licensed for treatment of COPD €90.00
1216 Zardaverine PDE3 and PDE4 inhibitor €75.00

11 Item(s)

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