Cardiovascular

The circulatory system is a vast network of organs and vessels that is responsible for the flow of blood, nutrients, oxygen and other gases, and hormones to and from cells. The system consists of three independent systems that work together: the heart (cardiovascular), lungs (pulmonary), and arteries, veins, coronary and portal vessels (systemic). Together, the heart, blood, and blood vessels make up the cardiovascular component of the circulatory system. It includes the pulmonary circulation, a "loop" through the lungs where blood is oxygenated. It also incorporates the systemic circulation, which runs through the rest of the body to provide oxygenated blood. 
Because of its vastness and critical nature, the circulatory system is one of the systems of the body most prone to disease. Disorders of this system are the leading cause of death among adults in the majority of countries world-wide, arteriosclerosis being one of  the most common diseases. It is characterized by  fatty deposits in the arteries that cause the walls to stiffen and thicken the walls, and may result in restricted blood flow and ischemia. This may result in symptoms such as angina and dyspnea, necrosis, and ultimately in heart attack or stroke. Hypertension, another circulatory is disease, causes the heart to work harder and can lead to complications as a heart attack, a stroke, or kidney failure. Abnormal blood lipid levels, that is high total cholesterol, high levels of triglycerides, high levels of low-density lipoprotein or low levels of high-density lipoprotein (HDL) cholesterol all increase the risk of heart disease and stroke, and are of particular interest of modern research. 
Besides changing food intake habits of patients suffering from cardiovascular diseases, in combination with the stimulation to increase physical exercise, special medication may also modify a patients blood lipid profile and prevent the person from developing life threatening circulatory diseases.

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Axon ID Name Description From price
3452 Verapamil hydrochloride Ca2+ channel antagonist €50.00
4111 TMDJ-035 First highly potent and selective RyR2 inhibitor  Recently added €130.00
4213 TMDJ-011 Inactive analogue of TMDJ-035  Recently added €120.00
1221 SKF 96365 hydrochloride Ca2+ channel blocker €105.00
3644 Propafenone hydrochloride Ca2+/K+/Na+ channel blocker; Antiarrhythmic agent €60.00
1823 Pregabalin Reduces synaptic signaling by binding to α2δ subunits €90.00
1274 PNU 37883 hydrochloride K+ channel blocker (ATP sensitive, vascular) €95.00
2068 Nifedipine Ca2+ channel blocker (L-type voltage gated) €55.00
3254 Nicardipine Ca2+ channel antagonist €50.00
4202 Manidipine dihydrochloride Ca2+ channel antagonist  Recently added €50.00
3501 Isradipine Ca2+ channel antagonist €60.00
1448 Felodipine Ca2+ channel blocker €65.00
2952 Fantofarone Highly potent and specific Ca2+ channel antagonist €125.00
3323 Diltiazem hydrochloride Ca2+ channel antagonist (L-type voltage gated) €50.00
1868 CRAC inhibitor 44 Potent and selective CRAC ion channel blocker €110.00
3036 BI 749327 Potent, selective and orally bioavailable TRPC6 inhibitor €160.00
3131 Benidipine hydrochloride Ca2+ channel blocker €70.00
1697 BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) €95.00
3014 Barnidipine hydrochloride Potent Ca2+ channel blocker (L-type voltage gated) €105.00
3160 Azelnidipine Calcium channel blocker €70.00
3013 Aranidipine Ca2+ channel antagonist €110.00
3015 Amlodipine besylate Ca2+ channel blocker €90.00
3631 ABR-238901 Potent S100A8/A9 blocker €170.00
1759 (S)-(-)-BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) €115.00
1758 (R)-(+)-BAY K 8644 Calcium (Ca2+) channel modulator €115.00

25 Item(s)

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