Cardiovascular

The circulatory system is a vast network of organs and vessels that is responsible for the flow of blood, nutrients, oxygen and other gases, and hormones to and from cells. The system consists of three independent systems that work together: the heart (cardiovascular), lungs (pulmonary), and arteries, veins, coronary and portal vessels (systemic). Together, the heart, blood, and blood vessels make up the cardiovascular component of the circulatory system. It includes the pulmonary circulation, a "loop" through the lungs where blood is oxygenated. It also incorporates the systemic circulation, which runs through the rest of the body to provide oxygenated blood. 
Because of its vastness and critical nature, the circulatory system is one of the systems of the body most prone to disease. Disorders of this system are the leading cause of death among adults in the majority of countries world-wide, arteriosclerosis being one of  the most common diseases. It is characterized by  fatty deposits in the arteries that cause the walls to stiffen and thicken the walls, and may result in restricted blood flow and ischemia. This may result in symptoms such as angina and dyspnea, necrosis, and ultimately in heart attack or stroke. Hypertension, another circulatory is disease, causes the heart to work harder and can lead to complications as a heart attack, a stroke, or kidney failure. Abnormal blood lipid levels, that is high total cholesterol, high levels of triglycerides, high levels of low-density lipoprotein or low levels of high-density lipoprotein (HDL) cholesterol all increase the risk of heart disease and stroke, and are of particular interest of modern research. 
Besides changing food intake habits of patients suffering from cardiovascular diseases, in combination with the stimulation to increase physical exercise, special medication may also modify a patients blood lipid profile and prevent the person from developing life threatening circulatory diseases.

Items 1 to 30 of 36 total

per page
Page:
  1. 1
  2. 2
Axon ID Name Description From price
1248 Zatebradine hydrochloride HCN channel blocker €110.00
1305 XE 991 dihydrochloride KCNQ channel and M-current blocker €90.00
1987 XE 991 KCNQ channel and M-current blocker €90.00
3265 XAF-1407 Potent and highly selective IKACh inhibitor €140.00
3799 VU6036721 hydrochloride Inactive enantiomer of VU6036720 hydrochloride €130.00
3675 VU6036720 hydrochloride First potent and selective inhibitor of heteromeric Kir4.1/5.1 inward rectifier potassium channels €130.00
3593 VU0468554 Selective cardiac GIRK inhibitor €110.00
3951 Senicapoc Potent and selective antagonist of the Gardos channel €65.00
1657 S 9947 Ikur/Kv1.5 channel Inhibitor €125.00
2252 Retigabine dihydrochloride KCNQ channel opener; Anti-convulsant €90.00
1525 Retigabine KCNQ channel opener; Anti-convulsant €90.00
2094 NS 6180 KCa3.1 channel blocker €90.00
2329 NS 19504 Potent activator of large-conductance Ca2+-activated potassium (BK) channels €90.00
2854 NS 1619 Selective activator of large-conductance Ca2+-activated potassium (BK) channels €95.00
1647 NN 414 K+ channel opener (SUR1/Kir6.2 selective) €110.00
3196 ML277 Potent and selective KCNQ1 channel activator €80.00
2615 ML252 Selective and brain penetrant KCNQ2 inhibitor €95.00
2840 ML 365 Potent and selective inhibitor of the TASK-1 potassium channel €135.00
3490 Minoxidil K+ channel opener (ATP sensitive, vascular) €50.00
3032 LUF7244 Potent negative allosteric modulator (NAM) of the Kv11.1 (hERG) channel €140.00
4046 Levosimendan Calcium sensitiser €60.00
1735 Kv1.3 Channel blocker 42 Kv1.3 potassium channel blocker €110.00
3516 KCa modulator RA-2 Potent and selective KCa2/3 pan inhibitor €110.00
3495 Ivabradine hydrochloride Selective sinus node I(f) channel inhibitor €50.00
2724 ICA-069673 KCNQ2/KCNQ3 channel opener; Anti-convulsant €90.00
1757 HMR 1098 K+ channel blocker (SUR1/Kir6.2 selective) €95.00
2064 Glibenclamide potassium salt KATP channel blocker; inhibits SUR1 €50.00
1437 Flupirtine maleate Analgesic €65.00
2103 Dofetilide Kv11.1 (hERG) channel blocker €85.00
1322 DMP 543 K+ channel blocker; Ach release stimulator €90.00

Items 1 to 30 of 36 total

per page
Page:
  1. 1
  2. 2
Please wait...