Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
1143 Aripiprazole Atypical antipsychotic €75.00
1144 Aripiprazole, thio- Atypical antipsychotic Inquire
1979 ARN 509 Antagonist of androgen receptor (AR) €95.00
1838 ARQ 197 c-MET tyrosine kinase Inhibitor €95.00
1503 Asenapine maleate Atypical antipsychotic €75.00
1675 Asoprisnil Progesterone receptor (PR) modulator €120.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
1371 Atipamezole hydrochloride α2 adrenoceptor antagonist €95.00
2692 AX-024 hydrochloride T cell receptor inhibitor €125.00
1747 AZ 12216052 Positive allosteric modulator (PAM) of mGluR8 €105.00
1610 AZ 23 TrkA and TrkB inhibitor €90.00
2340 AZ-GHS-22 Orally available Ghrelin receptor (GHS-R1a) inverse agonist €160.00
2145 AZD 1981 Selective CRTH2 (aka DP2) antagonist €105.00
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00
2563 AZD 3759 Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor €85.00

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