Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
1023 Aminotetraline hydrochloride, N-Methyl-N-propyl-2- Dopamine agonist Inquire
1064 Aminotetraline hydrochloride, Prop-2-ynyl-2- Dopamine agonist Inquire
1381 Amisulpride D2 and D3 antagonist €45.00
1207 Amthamine dihydrobromide H2 agonist €75.00
2368 Amuvatinib RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met €105.00
2468 ANA 12 Selective TrkB antagonist with anxiolytic and antidepressant activity in mice €90.00
1321 Antalarmin hydrochloride CRF1 antagonist €105.00
2541 APD 597 Orally bioavailable selective GPR119 agonist €125.00
2380 APD 668 Potent and selective, orally active GPR119 agonist €125.00
1369 Apilimod Cytokine inhibitor; IL-12 and IL-23 inhibitor Inquire
2500 Apilimod mesylate Cytokine inhibitor; IL-12 and IL-23 inhibitor Inquire
1486 Aprepitant Substance P antagonist (SPA); NK1 inhibitor €125.00
1572 AR 231453 Cannabinoid GPR119 agonist €85.00
2191 AR 244555 Inverse agonist of Mas G-protein signaling €140.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00

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