Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

Items 16 to 30 of 576 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Axon ID Name Description From price
2732 ADX71743 Negative allosteric modulator (NAM) of mGluR7  Recently added €105.00
1653 AEE 788 EGFR, ErbB2 and VEGFR tyrosine kinase inhibitor €95.00
1414 AG 013736 PDGFR,c-KIT and VEGFR tyrosine kinase inhibitor €75.00
1492 Agomelatine Melatonin agonist; 5-HT2C antagonist €75.00
1335 AH 001 Melatonin agonist €80.00
1336 AH 002 Melatonin agonist Inquire
2062 Alprostadil Prostaglandin EP (1-4) receptor antagonist €105.00
2367 AM 095 (parent compound) Novel potent and selective LPA1 antagonist €125.00
1218 AM 251 CB1 antagonist €95.00
1219 AM 281 CB1 antagonist €95.00
1648 Ambrisentan Endothelin-A (ETA) antagonist €80.00
1738 AMD 3100 CXCR4 antagonist €85.00
1930 AMD 3465 hexahydrobromide Potent and selective CXCR4 antagonist €85.00
1916 AMG 208 Inhibitor of c-MET receptor tyrosine kinase (RTK) €110.00
1768 AMG 706 Multiple receptor tyrosine kinase inhibitor €105.00

Items 16 to 30 of 576 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Please wait...