All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2930 Alofanib Allosteric inhibitor of FGFR2 €90.00
1917 AZD 4547 Potent and selective FGFR inhibitor €85.00
1981 LY 2874455 Potent and selective FGFR inhibitor €110.00
1775 NVP-BGJ398 Inhibitor of FGFR tyrosine kinases 1, 2 ,3 and 4 €90.00
1944 NVP-BGJ398 phosphate Inhibitor of FGFR tyrosine kinases 1, 2 ,3 and 4 €105.00
2098 PD 161570 Selective FGFR1 inhibitor €75.00
1673 PD 173074 FGFR1 and FGFR3 inhibitor €75.00
2953 Roblitinib First-in-class, highly selective and potent FGFR4 inhibitor €125.00
2234 SSR 128129E Allosteric inhibitor of FGF receptor signaling €99.00

9 Item(s)

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